Lab365.

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Bioengineering of novel organotypic 3D human liver tissue model for drug-induced liver injury and toxicity studies.

Nice paper on EpiLiver includes the supplemental qPCR data. 

Key words:  EpiLiver LIV-100, TEER, histology, H&E, immunohistochemistry, albumin production, drug transporters, drug-metabolizing enzymes, drug toxicity, 2D monolayer hepatocyte cultures, liver spheroids, Drug-induced liver injury DILI, alanine aminotransferase ALT, aspartate aminotransferase AST, midazolam, cytochrome CYP3A4, 1-hydroxymidazolam, fialuridine, Bosentan Hydrate, Diclofenac Sodium Salt, tolcapone, SN38, CK7, CD-10, ZO-1, TEER, histology H&E,  ABCB1/ MDR1, P-glycoprotein, P-gp, ABCC1,  multidrug resistance protein, MRP-1, ABCC2, MRP-2, ABCG2, breast cancer multidrug resistance protein, BCRP, CYP3A4, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A5, CYP3A7, CYP4A1, SLC,  MDR/TAP1, TAP2, VDAC1, VDAC2, ACTB, B2M, GAPDH, Aadac, Alcohol Dehydrogenase, ADH, CEL, Cytochrome P450, DHRS2, DPYD, ESD, Flavin containing monooxygenase, FMO1, GZMA, GZMB, HSD17B10, MAOA, MAOB, PTGS1, PTGS2, UCHL1, UCHL3, XDH, Actin beta, AANAT, ACSL1, ACSL3, ACSL4, ACSM1, ACSM2B, ACSM3, AGXT, AS3MT, ASMT, BAAT, CCBL1, Carboyxlesterase, CES1, CHST7, COMT, DDOST, EPHX1, EPHX2, GALNT1, GALNT4, GAMT, GCNT1, GLYAT, GNMT, GSTA1, Gluathione S-transferase, HNMT, INMT, Microsomal Gluathione S-transferase, NAA20, NAT1, NAT2, NNMT, NQO1, NQO2, PNMT, POMGNT1, PTGES, SAT1, Sulfotransferase, SULT1A1, TPMT, TST, UGCG, UDP glucuronosyltransferase, XDH

Materials tested:   fialuridine, Bosentan Hydrate, Diclofenac Sodium Salt, tolcapone, SN38, midazolam

Application area:  liver toxicity, metabolism, drug screening, hepatoxicity

 Skin@MatTek.co.kr