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ADVANCE YOUR 2-DIMENSIONAL RESEARCH INTO THE 3D WORLD

Safety Assessment • Efficacy Assessment • Target Validation

             Drug Discovery • Development • Delivery

INTERNATIONAL VALIDATIONS & SPECIAL STUDIES

* ECVAM/OECD TG 431 Skin Corrosion Test

* ECVAM/OECD TG 439 Skin Irritation Test

* COLGATE/IIVS Eye Irritation Validation

* ECVAM/COLIPA Eye Irritation Validation

* COLIPA Genotoxicity Pre-Validation

* ECVAM Phototoxicity Pre-Validation

* German Skin Penetration Validation

* COLIPA/BMBF Skin Metabolism Study

* Allergenicity Studies

* NIH Funded HIV/Anti-HIV Microbicide Research

* Airway Toxicity Validation

Standardized 3-D in vitro Tissue Models

* Normal (non-transformed) Human Cell-Derived Tissues

* Highly Reproducible, Lot-to-Lot and Year-to-Year

* Structurally, Biochemically Comparable to in vivo

* Mitotically and Metabolically Active

* No Cross-Species Extrapolation Errors

* Over 700 Technical References

TOXICOLOGY APPLICATIONS

* SKIN IRRITATION              * GENOTOXICITY

* SKIN CORROSION           * PHOTOTOXICITY  

* INFLAMMATION                * ALLERGENICITY

* OCULAR IRRITATION         * ORAL IRRITATION

* VAGINAL IRRITATION         * INHALATION TOXICITY

PHARMACEUTICAL APPLICATIONS

* DRUG DISCOVERY           * RESPIRATORY INFECTION

* DRUG DEVELOPMENT      * VAGINAL INFECTION

* DRUG DELIVERY              * DERMAL INFECTION

* ANTI-MELANOMA  DRUG SCREENING

* TUMOR INVASION            * ORAL INFECTION

COSMETIC EFFICACY SOLUTIONS

* ANTI-AGING                   * SKIN WHITENING

* UV PROTECTION            * SKIN PIGMENTATION

* WOUND HEALING           * COSMETIC EVALUATIONS

* ULTRA-MILDNESS OCULAR IRRITATION

About MatTek

MatTek Corporation is the world’s largest INDEPENDENT producer of in vitro human epithelial tissue equivalents. With nearly 20 YEARS of publicly available QC data and over 700 TECHNICAL REFERENCES supporting our claim of “Unsurpassed Long-Term Tissue Reproducibility”, MatTek human tissue equivalents are used in product development, claims substantiation (more than 200 PATENT REFERENCES cite the use of MatTek tissues), safety assessment, and drug discovery/ development in many industries including Cosmetics, Personal Care, Household Products, Chemicals, Pharmaceuticals and Biotech. MatTek produces normal (non-transformed), human cellderived, three dimensional, organotypic in vitro tissue equivalents. These tissues are proven alternatives to traditional animal testing, and enable genomic, proteomic, and drug delivery/discovery research not possible with traditional animal, monolayer cell culture or clinical test procedures.